New US monkeypox vaccine strategy could be huge boost for supply, but much is unknown

In an effort to stretch the limited supply of the Jynneos monkeypox vaccine, federal health officials this week authorized giving smaller doses using a different method of injection.
With more than 10,000 monkeypox cases in the United States and vaccine demand remaining high, Jynneos has been in short supply for weeks. The new injection strategy allows health-care providers to give shallow injections intradermally, in between layers of the skin, with one-fifth the standard dose size instead of subcutaneously, into the fatty layer below the skin, with the larger dose.

Yet the specific efficacy data for the vaccine is not clear, and some experts argue that not enough is known about how the low-dose intradermal strategy might affect the protection it provides in the real world.
Even at the original dosage size, “there is no traditional assessment of this vaccine,” Dr. Robert Califf, commissioner of the US Food and Drug Administration, said Tuesday. It’s approved for emergency purposes based on studies of immune responses, not clinical outcomes, because there haven’t been smallpox or monkeypox outbreaks large enough to test it.
The White House cited a clinical study published in 2015 that showed that two doses given intradermally at one-fifth the full amount produced a similar immune response to two full doses given subcutaneously, meaning people in both groups responded to vaccination in a similar way.
The intradermal route “may increase the number of available doses in an emergency situation,” the study’s findings say. Last week, the United States declared monkeypox to be a national public health emergency.


By: Miss Cherry May Timbol – Independent Reporter

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