Ulcer at mouth’s corner 1st sign of monkeypox virus infection: German researchers

“Monkeypox virus infection has also been reported in several species of squirrels, poached Gambian rats, dormice, and some species of monkeys.”

Ulcer at the corner of mouth has now been documented by scientists as the first sign of infection with monkeypox virus.

Recent infection with monkeypox virus can initially present with very few pronounced clinical symptoms and lacking signs of infection, and only few skin vesicles may be visible.

German researchers have now presented the case of a 51-year-old HIV-positive patient, whose ulcer at the corner of his mouth occurred as the first sign of infection with monkeypox virus.

According to Stefan Schlabe, University Hospital of Bonn, Department of Medicine, and colleagues, the patient presented to his general practitioner with a vesicle at the left corner of the mouth that had appeared the day before.A

“He had no clinical signs of infection; his HIV infection had been well controlled for years, both virologically and immunologically, with antiretroviral therapy,” said the study published in the journal Deutsches Arzteblatt international.

Initially, the patient’s ulcer was treated with a topical combination ointment.

Within a few days, he developed a painful ulcer at the left corner of his mouth and went back to his general practitioner. A swab was taken from the ulcer.

“Testing by polymerase chain reaction (PCR) confirmed monkeypox virus. Subsequently an increase in monkeypox vesicles was noted on the skin, but also on the palate,” the researchers noted.

With growing swelling of the base of the tongue and muffled speech, it was decided to admit the patient to hospital for antiviral treatment with tecovirimat, they added.
The monkeypox outbreak continues to be a global health emergency, which is the highest level of alert as per the World Health Organization (WHO).

RELATED: ‘Substantial’ pre-symptomatic monkeypox spread found

There is now more evidence for pre-symptomatic transmission of monkeypox virus. A study published recently in BMJ, which involves a larger cohort, found that pre-symptomatic transmission had taken place as long as four days before symptoms manifested. The researchers have estimated that 53% of monkeypox virus transmission have occurred during the pre-symptomatic phase. 



By: Miss Cherry May Timbol – Independent Reporter

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