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Luvox (fluvoxamine): Too Dangerous to Treat COVID
There have been recommendations for using Luvox (fluvoxamine) for the treatment of COVID.1 Years ago, it became apparent to me that fluvoxamine was the most dangerous SSRI antidepressant, causing high rates of mania and psychosis, and incidents of suicide and violence. In 2002, I wrote a report about Luvox for the International Journal of Risk & Safety in Medicine,2whereI marshaled considerable evidence for its dangerous array of adverse psychiatric events. I also summarized a single case report from the literature:
A single case study of a 17-year-old youngster taking fluvoxamine provides a window into what happened to Eric Harris.3 The youth, in this case, was mildly retarded when he became depressed and anxious and was started on a 50 mg dose of fluvoxamine. After a single dose, he developed “increasing agitation and insomnia.” Then, “In the next 24 hours, he displayed auditory and visual hallucinations, a fearful mood, and paranoid delusions involving statements that ‘the devil will get me’”. He required hospitalization and was treated with antipsychotic drugs.
Although fluvoxamine in the treatment of COVID-19 is recommended for only ten days, that relatively short period may not prevent its worst adverse psychiatric effects, which often occur early in treatment, as well as during changes of doses.4